Infrastructures

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RISE-Health is a clinical research unit focusing on cardiovascular, inflammatory and neurodegenerative diseases.

The unit has clinical research
facilities and infrastructures such
as medical consultation offices,
access to patients, pharmacokinetic
models and digital platforms.

We are equipped to support a range of clinical studies, including randomized clinical trials, with a focus on translational medicine.

RISE-Health is staffed with multidisciplinary teams, including basic scientists trained in various fields, and medical researchers from specialities like internal medicine, surgeons and cardiology.

The collaborative effort involves researchers, physicians, pharmacists, nurses, data scientists,economists, engineers, and psychologists, emphasizing the translational aspect of their research and development.

Clinical
research facilities

Medical Offices
Infrastructure for serial echocardiography evaluation and non-invasive phenotyping of patients with cardiovascular disease including long-term follow-up and support for researcher an industry-driven randomized clinical trials
Body Composition & Anthropometry Assessment Equipment
Functional Training & Rehabilitation Equipment
Cerebral Hemodynamics Laboratory
Neuro-ophthalmology Laboratory
Sensory tests laboratory
Pain and Therapeutic Adherence Research Center
Clinical Neurophysiology Lab
Laboratory enable to perform Transcranial Magnetic Stimulation

Biomedical Engineering Facilities

Biomedical Simulation Centre
Virtual Patient Simulator

Biomedical
Imaging Facilities

Advanced Confocal Microscopy, Photoactivation and Biomedical Imaging Facility
Ultrastructural microscopy lab (including timelapse, live imaging and fluorescence), including drug screening and biomarkers
Electrophysiology (patch-clamp and extracellular recordings) synchronized with fluorescence bioimaging (e.g., single-cell Calcium signals, membrane potential)
Laser Scanning Microdissection mounted on an Epifluorescence Microscope
Radioactivity – Beta Scintillation Spectrometry
MR imaging 3T

Cell Culture
Facilities

Cell and tissue culture facilities qualified to set up immortalized cell line models as well as primary cell cultures from either healthy or diseased tissues
Facilities dedicated to cardiovascular function evaluation from intact cardiomyocytes and muscle strips ex vivo to pressure-volume loops in vivo for preclinical and translational research
Flow cytometry unit
Cell Culture Laboratory
Laboratory of neuroinflammatory and neurodegenerative biomarkers

Environmental Health
Research Facilities

Environmental & Occupation Health Lab (LASA)

Genomic, Transcriptomic, Proteomics and Metabolomics Facilities

Molecular Biology Lab For Genomic, Proteomic and Spectrometry Studies – Laboratories for cytometry, physiology, chromatography, microbiology, proteomics, microcalorimetry, organic synthesis, biotechnological orpharmaceutical technology
Nuclear Magnetic Resonance (NMR) Facility equipped with spectrometer for routine structural analysis, and for metabolomic studies

Collections of Biological Resources

Cohorts of patients with heart failure (with both reduced and preserved ejection fraction) and acute coronary syndromes, along with anextensive registry and database of cardiac surgical patients, both featuring tissue and blood sample biobanks
Cohorts of patients with drug-resistant mesotemporal lobe epilepsy (MTLE) and myasthenia gravis, urine and tissue samples from patients with overactive bladder, bone marrow from post-menopausal women and age-matched control men.

bio-informatics facilities

Bioinformatics Lab

animal facilities

Licensed animal housing for small and large animal models of disease and therapy (including genetically manipulated small animal models)
Licensed animal housing with breeding and experimentation areas, including space for behavioral studies and surgical procedures

Health Data Facilities & Software

Facilities properly equipped to support fundamental technologies, research and development activities in the area of digital health and applications of sufficiently robust computing resources for data science, machine-learning and advanced modelling tools.

Other Equipment

EEG, EMG and Evoked potentials
Sensing DBS
EEG with Cognitrace and eego mylab software
HD-tDCS systems
Visual electrophysiology with bandolet and pediatric stimulator
Multifunction perimeter
SD-Optical coherence tomography with Angio OCT
Eye tracking headset and platform
Refraction unit with slit lamp and optotype chart monitor
TMS system
TMS neuronavigator
BrainLoop Lab
Neuromodulation laboratory
Powerlab for peripheral recordings
Neuroprax TMS
Neuroconn DC Stimulator + MR compatible
Neuroconn LOOP IT
Wireless EEG device
Magventure TMS stimulator