{"id":7078,"date":"2026-08-24T08:00:00","date_gmt":"2026-08-24T08:00:00","guid":{"rendered":"https:\/\/rise-health.pt\/?p=7078"},"modified":"2026-09-03T08:28:14","modified_gmt":"2026-09-03T08:28:14","slug":"solucao-nasal-inovadora-reduz-lesoes-cerebrais-e-melhora-recuperacao-da-capacidade-motora-apos-avc","status":"publish","type":"post","link":"https:\/\/rise-health.pt\/pt-pt\/2026\/08\/24\/solucao-nasal-inovadora-reduz-lesoes-cerebrais-e-melhora-recuperacao-da-capacidade-motora-apos-avc\/","title":{"rendered":"Solu\u00e7\u00e3o nasal inovadora reduz les\u00f5es cerebrais e melhora recupera\u00e7\u00e3o da capacidade motora ap\u00f3s AVC"},"content":{"rendered":"\t\t
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Solu\u00e7\u00e3o nasal inovadora reduz les\u00f5es cerebrais e melhora recupera\u00e7\u00e3o da capacidade motora ap\u00f3s AVC<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Investiga\u00e7\u00e3o da RISE-Health abre caminho a nova abordagem terap\u00eautica para o AVC isqu\u00e9mico.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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O recurso a uma \u201cnova solu\u00e7\u00e3o\u201d nasal pode melhorar a recupera\u00e7\u00e3o motora e reduzir as les\u00f5es cerebrais ap\u00f3s acidente vascular cerebral isqu\u00e9mico. Esta \u00e9 uma das conclus\u00f5es de um estudo internacional liderado pela RISE-Health<\/strong> e pela Universidade da Beira Interior<\/strong> (UBI), focado numa das principais causas de incapacidade a n\u00edvel global.<\/p>\n

O trabalho cient\u00edfico, realizado em modelos animais, demonstrou que a administra\u00e7\u00e3o, pouco tempo ap\u00f3s o AVC, por via nasal, de uma \u00fanica dose baixa de Nestorona\u00ae \u2014 uma subst\u00e2ncia criada em laborat\u00f3rio que imita uma das hormonas protetoras do organismo \u2014 reduz significativamente a extens\u00e3o dos danos no tecido cerebral provocados pelo AVC e melhora a recupera\u00e7\u00e3o da capacidade motora.<\/p>\n

De acordo com Sara Meirinho<\/strong>, investigadora da RISE-Health, a via oral convencional compromete o aproveitamento da Nestorona\u00ae, f\u00e1rmaco atualmente utilizado para fins contraceptivos.<\/p>\n

“Quando administrado por via oral, a Nestoron<\/em>a\u00ae<\/em> perde grande parte do seu potencial, com menos de 10% da subst\u00e2ncia a alcan\u00e7ar a circula\u00e7\u00e3o sangu\u00ednea devido \u00e0 degrada\u00e7\u00e3o no f\u00edgado. A via nasal surge como a alternativa ideal para contornar este obst\u00e1culo. Permite evitar o metabolismo de primeira passagem hep\u00e1tico e possibilita que parte do f\u00e1rmaco alcance o c\u00e9rebro diretamente atrav\u00e9s dos nervos olfativos e trigeminais, tornando esta zona anat\u00f3mica altamente interessante para tratar doen\u00e7as neurol\u00f3gicas”, explica a especialista.<\/p>\n

Segundo os investigadores da RISE-Health<\/strong>, a administra\u00e7\u00e3o deste f\u00e1rmaco por via nasal permitiu uma chegada ao c\u00e9rebro extremamente r\u00e1pida. Apenas cinco minutos ap\u00f3s a administra\u00e7\u00e3o nasal<\/strong>, a Nestorona\u00ae<\/em> atingiu o pico de concentra\u00e7\u00e3o m\u00e1xima no c\u00e9rebro, alcan\u00e7ando assim uma exposi\u00e7\u00e3o cerebral ao f\u00e1rmaco cerca de duas vezes superior \u00e0 obtida por outras vias convencionais, como a inje\u00e7\u00e3o subcut\u00e2nea.<\/p>\n

Descoberta pode ter impacto em diversas patologias<\/strong><\/h3>\n

O potencial desta descoberta, contudo, n\u00e3o se esgota no AVC. A equipa liderada pela maior Unidade de Investiga\u00e7\u00e3o do pa\u00eds antecipa que esta abordagem possa vir a ser transposta para outras patologias.<\/p>\n

\u201cAl\u00e9m de reduzir les\u00f5es cerebrais ap\u00f3s o AVC, h\u00e1 ind\u00edcios de que a Nestorona\u00ae<\/em> pode ter uma enorme relev\u00e2ncia terap\u00eautica no tratamento de outras doen\u00e7as do sistema nervoso central, como a esclerose m\u00faltipla\u201d, aponta a especialista da RISE-Health.<\/p>\n

Os investigadores refor\u00e7am que estes dados resultam exclusivamente de estudos em modelos animais, sendo agora necess\u00e1rio avan\u00e7ar para ensaios cl\u00ednicos que confirmem a seguran\u00e7a e a efic\u00e1cia desta abordagem em humanos.<\/p>\n

O estudo \u201cLow dose intranasal nestorone self-emulsifying drug delivery system promotes neuroprotection in experimental stroke through modulation of glial cells\u201d<\/em>, publicado na Drug Delivery and Translational Research<\/a>, \u00e9 liderado por Sara Meirinho e conta com Adriana Santos, Susana Alves Ferreira, Catarina Diniz, Gilberto Alves e Gra\u00e7a Baltazar, investigadores da Unidade de Investiga\u00e7\u00e3o RISE-Health e da UBI, como autores. A iniciativa conta tamb\u00e9m com a participa\u00e7\u00e3o de especialistas de Espanha e dos Estados Unidos da Am\u00e9rica.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Cerca de 300 investigadores de todo o pa\u00eds juntaram-se na Faculdade de Medicina da Universidade do Porto (FMUP), no dia 28 de junho, para participarem na 1.\u00aa Reuni\u00e3o de Trabalho da nova Unidade de Investiga\u00e7\u00e3o RISE-Health, nascida da fus\u00e3o de duas Unidades de Investiga\u00e7\u00e3o sediadas na FMUP, o CINTESIS e a UnIC, \u00e0s quais se juntaram o MedInUP e o CICS \u2013 Universidade da Beira Interior.<\/p>\n","protected":false},"author":6,"featured_media":7079,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[355,357,356,147],"class_list":["post-7078","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias","tag-avc","tag-sara-meirinho","tag-solucao-nasal","tag-ubi"],"yoast_head":"\nSolu\u00e7\u00e3o nasal inovadora reduz les\u00f5es cerebrais e melhora recupera\u00e7\u00e3o da capacidade motora ap\u00f3s AVC<\/title>\n<meta name=\"description\" content=\"Investiga\u00e7\u00e3o da RISE-Health abre caminho a nova abordagem terap\u00eautica para o AVC isqu\u00e9mico.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rise-health.pt\/pt-pt\/2026\/08\/24\/solucao-nasal-inovadora-reduz-lesoes-cerebrais-e-melhora-recuperacao-da-capacidade-motora-apos-avc\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Solu\u00e7\u00e3o nasal inovadora reduz les\u00f5es cerebrais e melhora recupera\u00e7\u00e3o da capacidade motora ap\u00f3s AVC\" \/>\n<meta property=\"og:description\" content=\"Investiga\u00e7\u00e3o da RISE-Health abre caminho a nova abordagem terap\u00eautica para o AVC isqu\u00e9mico.\" \/>\n<meta property=\"og:url\" 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