{"id":7038,"date":"2026-07-29T15:53:35","date_gmt":"2026-07-29T15:53:35","guid":{"rendered":"https:\/\/rise-health.pt\/?p=7038"},"modified":"2026-08-14T14:12:57","modified_gmt":"2026-08-14T14:12:57","slug":"farmacos-para-asma-e-coracao-podem-ajudar-a-tratar-cancro-da-bexiga","status":"publish","type":"post","link":"https:\/\/rise-health.pt\/pt-pt\/2026\/07\/29\/farmacos-para-asma-e-coracao-podem-ajudar-a-tratar-cancro-da-bexiga\/","title":{"rendered":"F\u00e1rmacos para asma e cora\u00e7\u00e3o podem ajudar a tratar cancro da bexiga"},"content":{"rendered":"\t\t
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F\u00e1rmacos para asma e cora\u00e7\u00e3o podem ajudar a tratar cancro da bexiga<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Proposta de investigadores da RISE-Health e FMUP vai permitir “reduzir o tempo, o custo e o risco associados ao desenvolvimento de novas terap\u00eauticas”.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u00a0<\/p>

Os medicamentos cardiovasculares, especificamente aqueles que alteram a for\u00e7a de contra\u00e7\u00e3o do m\u00fasculo card\u00edaco, a par de f\u00e1rmacos utilizados na gest\u00e3o da asma, podem ser uma \u201cnova solu\u00e7\u00e3o\u201d para o tratamento do cancro da bexiga.\u00a0A conclus\u00e3o \u00e9 de um\u00a0estudo da Unidade de Investiga\u00e7\u00e3o RISE Health e da Faculdade de Medicina da Universidade do Porto (FMUP)<\/strong>, que procurou estudar a potencial reutiliza\u00e7\u00e3o de f\u00e1rmacos associados a patologias como a insufici\u00eancia card\u00edaca e a asma no tratamento deste tipo de cancro.<\/p>

Os resultados, obtidos em ensaios laboratoriais com c\u00e9lulas de cancro da bexiga, ainda est\u00e3o numa fase inicial e distante da aplica\u00e7\u00e3o cl\u00ednica. Contudo, \u201cconstat\u00e1mos que estes f\u00e1rmacos \u2013 milrinone e terbutalina \u2013 potenciaram significativamente os efeitos anticancer\u00edgenos do 5-FU, medicamento de quimioterapia, nas c\u00e9lulas cancer\u00edgenas da bexiga [\u2026], o que indica um benef\u00edcio espec\u00edfico para este tipo de tumor\u201d, pode ler-se no trabalho cient\u00edfico publicado na revista\u00a0Cancers<\/a><\/em>.<\/p>

De acordo com o trabalho liderado por\u00a0Nuno Vale<\/strong>\u00a0e\u00a0Eduarda Ribeiro<\/strong>, investigadores da RISE-Health e da FMUP, \u201ca terbutalina modulou o stress oxidativo provocado pelo 5-FU nas c\u00e9lulas de cancro da bexiga. Este resultado \u00e9 particularmente interessante porque o stress oxidativo influencia a resposta celular \u00e0 quimioterapia e pode estar envolvido nos mecanismos de adapta\u00e7\u00e3o e resist\u00eancia tumoral\u201d.<\/p>

Segundo os especialistas, o reaproveitamento de f\u00e1rmacos permite \u201creduzir o tempo, o custo e o risco associados ao desenvolvimento de novas terap\u00eauticas\u201d, explicando que a milrinone e a terbutalina, quando combinadas com o 5-FU, diminu\u00edram a capacidade das c\u00e9lulas de migrarem e de formarem novas col\u00f3nias, dois comportamentos associados \u00e0 progress\u00e3o e \u00e0 persist\u00eancia do tumor.<\/p>

\u00a0<\/h2>

Os pr\u00f3ximos passos<\/h2>

Nuno Vale<\/strong>\u00a0e\u00a0Eduarda Ribeiro<\/strong>\u00a0acrescentam que \u201co objetivo futuro n\u00e3o ser\u00e1, por isso, administrar estas combina\u00e7\u00f5es indiscriminadamente a todos os doentes com cancro da bexiga\u201d, real\u00e7ando que \u201cuma estrat\u00e9gia verdadeiramente personalizada dever\u00e1 ainda integrar informa\u00e7\u00e3o cl\u00ednica, molecular e funcional de cada paciente.<\/p>

Al\u00e9m da an\u00e1lise gen\u00e9tica e prote\u00f3mica do tumor, poder\u00e3o ser utilizados organoides ou culturas de c\u00e9lulas derivadas do pr\u00f3prio doente para testar, em laborat\u00f3rio, a resposta \u00e0s diferentes combina\u00e7\u00f5es antes da decis\u00e3o terap\u00eautica\u201d.<\/p>

\u201cO potencial desta investiga\u00e7\u00e3o n\u00e3o reside apenas na identifica\u00e7\u00e3o de dois medicamentos que poder\u00e3o aumentar o efeito do 5-FU. Reside tamb\u00e9m na possibilidade de construir uma abordagem em que o tratamento seja selecionado com base nas caracter\u00edsticas espec\u00edficas do tumor de cada doente, procurando maximizar a efic\u00e1cia e reduzir tratamentos desnecess\u00e1rios, toxicidade e risco de resist\u00eancia\u201d, concluem os investigadores.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Cerca de 300 investigadores de todo o pa\u00eds juntaram-se na Faculdade de Medicina da Universidade do Porto (FMUP), no dia 28 de junho, para participarem na 1.\u00aa Reuni\u00e3o de Trabalho da nova Unidade de Investiga\u00e7\u00e3o RISE-Health, nascida da fus\u00e3o de duas Unidades de Investiga\u00e7\u00e3o sediadas na FMUP, o CINTESIS e a UnIC, \u00e0s quais se juntaram o MedInUP e o CICS \u2013 Universidade da Beira Interior.<\/p>\n","protected":false},"author":6,"featured_media":7039,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[128,347,346,152,345],"class_list":["post-7038","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias","tag-cancro","tag-cancro-da-bexiga","tag-eduarda-ribeiro","tag-fmup","tag-nuno-vale"],"yoast_head":"\nF\u00e1rmacos para asma e cora\u00e7\u00e3o podem ajudar a tratar cancro da bexiga<\/title>\n<meta name=\"description\" content=\"Proposta de investigadores da RISE-Health e FMUP vai permitir "reduzir o tempo, o custo e o risco associados ao desenvolvimento de novas terap\u00eauticas".\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rise-health.pt\/pt-pt\/2026\/07\/29\/farmacos-para-asma-e-coracao-podem-ajudar-a-tratar-cancro-da-bexiga\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"F\u00e1rmacos para asma e cora\u00e7\u00e3o podem ajudar a tratar cancro da bexiga\" \/>\n<meta property=\"og:description\" content=\"Proposta de investigadores da RISE-Health e FMUP vai permitir "reduzir o tempo, o custo e o risco associados ao desenvolvimento de novas terap\u00eauticas".\" \/>\n<meta property=\"og:url\" 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