{"id":6436,"date":"2026-06-08T10:54:16","date_gmt":"2026-06-08T10:54:16","guid":{"rendered":"https:\/\/rise-health.pt\/?p=6436"},"modified":"2026-06-08T10:54:44","modified_gmt":"2026-06-08T10:54:44","slug":"recetores-de-sabor-amargo-podem-aumentar-a-eficacia-do-tratamento-de-tumor-cerebral-altamente-agressivo","status":"publish","type":"post","link":"https:\/\/rise-health.pt\/pt-pt\/2026\/06\/08\/recetores-de-sabor-amargo-podem-aumentar-a-eficacia-do-tratamento-de-tumor-cerebral-altamente-agressivo\/","title":{"rendered":"Recetores de sabor amargo podem aumentar a efic\u00e1cia do tratamento de tumor cerebral altamente agressivo"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"6436\" class=\"elementor elementor-6436\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-96c1d45 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"96c1d45\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0a1baba\" data-id=\"0a1baba\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5bbab76 elementor-widget elementor-widget-heading\" data-id=\"5bbab76\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Recetores de sabor amargo podem aumentar a efic\u00e1cia do tratamento de tumor cerebral altamente agressivo<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-70975945 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"70975945\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6729ebf2\" data-id=\"6729ebf2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5d946cdb elementor-widget elementor-widget-text-editor\" data-id=\"5d946cdb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Investiga\u00e7\u00e3o da RISE-Health abre nova frente no combate ao glioblastoma<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4734a99 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4734a99\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2dd3bbb\" data-id=\"2dd3bbb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d5e316f elementor-widget elementor-widget-image\" data-id=\"d5e316f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"2560\" height=\"1707\" src=\"https:\/\/rise-health.pt\/wp-content\/uploads\/2026\/06\/pexels-tima-miroshnichenko-6011602-1-scaled.jpg\" class=\"attachment-full size-full wp-image-6406\" alt=\"\" srcset=\"https:\/\/rise-health.pt\/wp-content\/uploads\/2026\/06\/pexels-tima-miroshnichenko-6011602-1-scaled.jpg 2560w, https:\/\/rise-health.pt\/wp-content\/uploads\/2026\/06\/pexels-tima-miroshnichenko-6011602-1-300x200.jpg 300w, https:\/\/rise-health.pt\/wp-content\/uploads\/2026\/06\/pexels-tima-miroshnichenko-6011602-1-1024x683.jpg 1024w, https:\/\/rise-health.pt\/wp-content\/uploads\/2026\/06\/pexels-tima-miroshnichenko-6011602-1-768x512.jpg 768w, https:\/\/rise-health.pt\/wp-content\/uploads\/2026\/06\/pexels-tima-miroshnichenko-6011602-1-1536x1024.jpg 1536w, https:\/\/rise-health.pt\/wp-content\/uploads\/2026\/06\/pexels-tima-miroshnichenko-6011602-1-2048x1365.jpg 2048w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-15b4243 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"15b4243\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cc632e6\" data-id=\"cc632e6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4ff0561 elementor-widget elementor-widget-text-editor\" data-id=\"4ff0561\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0<\/p><p>Os recetores de sabor amargo poder\u00e3o vir a desempenhar um papel importante no combate ao glioblastoma, o tumor cerebral maligno mais agressivo e um dos mais dif\u00edceis de tratar. A conclus\u00e3o \u00e9 de um estudo liderado pela <strong>RISE-Health<\/strong>, que identifica estes recetores como um novo potencial biomarcador e alvo terap\u00eautico para este tipo de cancro.<\/p><p>Conhecidos pelo seu papel na dete\u00e7\u00e3o de subst\u00e2ncias potencialmente t\u00f3xicas atrav\u00e9s do paladar, os recetores de sabor amargo \u2014 designados TAS2Rs \u2014 parecem tamb\u00e9m influenciar o comportamento das c\u00e9lulas tumorais e a resposta aos tratamentos. Estes recetores s\u00e3o ativados por compostos amargos que, ao ligarem-se a eles, desencadeiam respostas celulares.<\/p><p>\u201cA ativa\u00e7\u00e3o dos recetores de sabor amargo n\u00e3o est\u00e1 apenas associada ao paladar. Sabe-se agora que estes recetores desempenham fun\u00e7\u00f5es nas c\u00e9lulas tumorais e podem influenciar diferentes processos, como a viabilidade celular e, especialmente, a resposta ao tratamento\u201d, explicam <strong>Cec\u00edlia Santos<\/strong> e <strong>Ana Raquel Costa<\/strong>, especialistas da Unidade de Investiga\u00e7\u00e3o <strong>RISE-Health<\/strong> e da Universidade da Beira Interior.<\/p><p>Segundo as investigadoras, o estudo demonstra que a ativa\u00e7\u00e3o destes recetores poder\u00e1 aumentar a efic\u00e1cia da temozolomida, o principal f\u00e1rmaco utilizado no tratamento do glioblastoma.<\/p><p>\u201cOs resultados sugerem que os recetores de sabor amargo podem impedir as c\u00e9lulas tumorais de desenvolver resist\u00eancia \u00e0 temozolomida, um dos principais desafios no tratamento deste tumor\u201d, acrescentam.<\/p><p>Al\u00e9m do potencial impacto no glioblastoma, os investigadores acreditam que os TAS2Rs poder\u00e3o tamb\u00e9m ter um papel relevante noutros tipos de cancro. Evid\u00eancias cient\u00edficas recentes apontam para fun\u00e7\u00f5es antitumorais destes recetores em tumores s\u00f3lidos como o glioblastoma, o cancro da mama e tumores gastrointestinais, contribuindo para reduzir a prolifera\u00e7\u00e3o e migra\u00e7\u00e3o celular.<\/p><p>O trabalho cient\u00edfico, publicado na revista International Journal of Molecular Sciences, identifica os recetores de sabor amargo como uma nova via promissora para compreender e combater a resist\u00eancia terap\u00eautica no glioblastoma.<\/p><p>Os investigadores apontam, como pr\u00f3ximo passo, o estudo da variabilidade na express\u00e3o destes recetores entre doentes, o que poder\u00e1 no futuro influenciar a forma como o tratamento \u00e9 personalizado.<\/p><p>O estudo, intitulado Bitter Taste Signalling via TAS2R43 Enhances Temozolomide Efficacy in Glioblastoma Cells, foi liderado por Cec\u00edlia Santos e Ana Raquel Costa e contou ainda com a participa\u00e7\u00e3o dos investigadores Ana Catarina Duarte, Isabel Gon\u00e7alves, Jos\u00e9 Cascalheira e Helena Marcelino, da RISE-Health, bem como de Robert Preissner, da Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-699705a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"699705a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-171296d\" data-id=\"171296d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d10fafe elementor-widget elementor-widget-spacer\" data-id=\"d10fafe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Cerca de 300 investigadores de todo o pa\u00eds juntaram-se na Faculdade de Medicina da Universidade do Porto (FMUP), no dia 28 de junho, para participarem na 1.\u00aa Reuni\u00e3o de Trabalho da nova Unidade de Investiga\u00e7\u00e3o RISE-Health, nascida da fus\u00e3o de duas Unidades de Investiga\u00e7\u00e3o sediadas na FMUP, o CINTESIS e a UnIC, \u00e0s quais se juntaram o MedInUP e o CICS \u2013 Universidade da Beira Interior.<\/p>\n","protected":false},"author":6,"featured_media":6404,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[128,313,147],"class_list":["post-6436","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias","tag-cancro","tag-glioblastoma","tag-ubi"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Recetores de sabor amargo podem aumentar a efic\u00e1cia do tratamento de tumor cerebral altamente agressivo<\/title>\n<meta name=\"description\" content=\"Os recetores de sabor amargo poder\u00e3o vir a desempenhar um papel importante no combate ao glioblastoma, o tumor cerebral maligno mais agressivo\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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