{"id":6147,"date":"2026-04-28T08:28:01","date_gmt":"2026-04-28T08:28:01","guid":{"rendered":"https:\/\/rise-health.pt\/?p=6147"},"modified":"2026-04-28T08:36:53","modified_gmt":"2026-04-28T08:36:53","slug":"alteracoes-moleculares-prever-evolucao-do-cancro-em-criancas-e-jovens-adultos","status":"publish","type":"post","link":"https:\/\/rise-health.pt\/pt-pt\/2026\/04\/28\/alteracoes-moleculares-prever-evolucao-do-cancro-em-criancas-e-jovens-adultos\/","title":{"rendered":"Altera\u00e7\u00f5es moleculares espec\u00edficas podem prever evolu\u00e7\u00e3o do cancro da tiroide em crian\u00e7as e jovens adultos"},"content":{"rendered":"\t\t
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Altera\u00e7\u00f5es moleculares espec\u00edficas podem prever evolu\u00e7\u00e3o do cancro da tiroide em crian\u00e7as e jovens adultos<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Estudo da RISE-Health e da FMUP abre caminho a tratamento mais personalizado de tumores da tiroide em crian\u00e7as e jovens at\u00e9 aos 25 anos.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u00a0<\/p>

Um grupo internacional de investigadores, liderado por Sule Canberk<\/strong>, investigadora da Unidade de Investiga\u00e7\u00e3o RISE-Health<\/strong> e docente da Faculdade de Medicina da Universidade do Porto (FMUP), demonstrou que determinadas altera\u00e7\u00f5es moleculares som\u00e1ticas do tumor da tiroide est\u00e3o associadas a diferentes progn\u00f3sticos desta patologia em crian\u00e7as, adolescentes e jovens adultos.<\/p>

O estudo publicado na European Thyroid Journal, uma revista de refer\u00eancia a n\u00edvel europeu, demonstrou que o perfil molecular do tumor da tiroide tem valor progn\u00f3stico independente da idade, do sexo e da dura\u00e7\u00e3o do seguimento, contribuindo para prever a evolu\u00e7\u00e3o cl\u00ednica destes doentes.<\/strong><\/p>

Esta descoberta, de acordo com a especialista, indica que a idade n\u00e3o deve ser tratada apenas como um descritor demogr\u00e1fico na avalia\u00e7\u00e3o de n\u00f3dulos tireoidianos em crian\u00e7as e jovens<\/strong>, real\u00e7ando que as recomenda\u00e7\u00f5es atuais de tratamento desta patologia n\u00e3o estabelecem, de forma expl\u00edcita, uma estratifica\u00e7\u00e3o da abordagem dentro da popula\u00e7\u00e3o pedi\u00e1trica.<\/p>

\u201cAs fus\u00f5es [dos genes] NTRK1\/3 e RET, mais prevalentes nos doentes mais jovens, associaram-se a desfechos menos favor\u00e1veis, enquanto o BRAF V600E, mais frequente na adolesc\u00eancia, apresentou um perfil de risco interm\u00e9dio; as muta\u00e7\u00f5es RAS mostraram uma tend\u00eancia favor\u00e1vel e, na nossa s\u00e9rie, todos os casos com altera\u00e7\u00e3o DICER1 tiveram uma resposta excelente\u201d, revela Sule Canberk (RISE-Health\/FMUP).<\/p>

\u00a0<\/h3>

O futuro do diagn\u00f3stico e tratamento<\/h3>

Segundo o trabalho cient\u00edfico, a caracteriza\u00e7\u00e3o molecular de tumores da tiroide em fases precoces da vida pode contribuir para uma estratifica\u00e7\u00e3o de risco mais precisa, abrindo caminho a decis\u00f5es cl\u00ednicas mais informadas, nomeadamente ao n\u00edvel do seguimento e da personaliza\u00e7\u00e3o terap\u00eautica.<\/p>

\u201cNeste estudo, demonstr\u00e1mos que o tipo de altera\u00e7\u00e3o molecular mant\u00e9m valor progn\u00f3stico independente mesmo ap\u00f3s ajuste para idade, sexo e dura\u00e7\u00e3o do seguimento\u201d, <\/strong>esclarece a patologista end\u00f3crina.<\/p>

De acordo com a tamb\u00e9m docente da FMUP, \u201ca integra\u00e7\u00e3o sistem\u00e1tica da an\u00e1lise molecular poder\u00e1 melhorar a estratifica\u00e7\u00e3o do risco e apoiar decis\u00f5es cl\u00ednicas mais informadas. Tal permitir\u00e1 ir al\u00e9m da idade e do estadiamento cl\u00ednico e estimar melhor o risco com base no comportamento biol\u00f3gico do tumor\u201d.<\/p>

\u201cCom base nestes resultados, estamos atualmente a desenvolver uma ferramenta algor\u00edtmica com o objetivo de refinar a abordagem pr\u00e9 e p\u00f3s-operat\u00f3ria dos doentes atrav\u00e9s do uso combinado de faixas et\u00e1rias de desenvolvimento, citologia, histopatologia, perfil molecular e dados de seguimento cl\u00ednico\u201d, conclui a investigadora.<\/p>

Intitulado \u201cThe influence of age-independent somatic driver alterations on clinical outcomes in paediatric and young adult thyroid cancer\u201d, o estudo liderado por Sule Canberk<\/strong> (RISE-Health\/FMUP) teve Fernando Schmitt<\/strong> (RISE-Health@RISE\/FMUP) como coautor. A investiga\u00e7\u00e3o contou ainda com especialistas da Turquia, It\u00e1lia e EUA.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Cerca de 300 investigadores de todo o pa\u00eds juntaram-se na Faculdade de Medicina da Universidade do Porto (FMUP), no dia 28 de junho, para participarem na 1.\u00aa Reuni\u00e3o de Trabalho da nova Unidade de Investiga\u00e7\u00e3o RISE-Health, nascida da fus\u00e3o de duas Unidades de Investiga\u00e7\u00e3o sediadas na FMUP, o CINTESIS e a UnIC, \u00e0s quais se juntaram o MedInUP e o CICS \u2013 Universidade da Beira Interior.<\/p>\n","protected":false},"author":6,"featured_media":6121,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[128,296,22,299],"class_list":["post-6147","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias","tag-cancro","tag-cancro-da-tiroide","tag-rise-health","tag-sule-canberk"],"yoast_head":"\nAltera\u00e7\u00f5es moleculares espec\u00edficas podem prever evolu\u00e7\u00e3o do cancro da tiroide em crian\u00e7as e jovens adultos<\/title>\n<meta name=\"description\" content=\"Estudo da RISE-Health e da FMUP abre caminho a tratamento mais personalizado de tumores da tiroide em crian\u00e7as e jovens at\u00e9 aos 25 anos.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rise-health.pt\/pt-pt\/2026\/04\/28\/alteracoes-moleculares-prever-evolucao-do-cancro-em-criancas-e-jovens-adultos\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Altera\u00e7\u00f5es moleculares espec\u00edficas podem prever evolu\u00e7\u00e3o do cancro da tiroide em crian\u00e7as e jovens adultos\" \/>\n<meta property=\"og:description\" content=\"Estudo da RISE-Health e da FMUP abre caminho a tratamento mais personalizado de tumores da tiroide em crian\u00e7as e jovens at\u00e9 aos 25 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